The Moderna trial exhibited a 6 % higher risk of serious adverse events in the vaccine group: risk difference 7.1 per 10,000 (95 % CI -23.2 to 37.4) risk ratio 1.06 (95 % CI 0.84 to 1.33). The Pfizer trial exhibited a 36 % higher risk of serious adverse events in the vaccine group risk difference 18.0 per 10,000 vaccinated (95 % CI 1.2 to 34.9) risk ratio 1.36 (95 % CI 1.02 to 1.83). Combined, the mRNA vaccines were associated with an excess risk of serious adverse events of special interest of 12.5 per 10,000 vaccinated (95 % CI 2.1 to 22.9) risk ratio 1.43 (95 % CI 1.07 to 1.92). Pfizer and Moderna mRNA COVID-19 vaccines were associated with an excess risk of serious adverse events of special interest of 10.1 and 15.1 per 10,000 vaccinated over placebo baselines of 17.6 and 42.2 (95 % CI -0.4 to 20.6 and -3.6 to 33.8), respectively. Secondary analysis of serious adverse events reported in the placebo-controlled, phase III randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines in adults ( NCT04368728 and NCT04470427), focusing analysis on Brighton Collaboration adverse events of special interest. We adapted the Brighton Collaboration list to evaluate serious adverse events of special interest observed in mRNA COVID-19 vaccine trials. If you have a history of allergies, or if you had a reaction immediately after a previous dose, you may also be advised to stay for 15 minutes after the vaccine.In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines. Waiting time after your coronavirus vaccinationīecause of a small risk of fainting, you should not drive for at least 15 minutes after your vaccination. While other changes to periods have been reported by some people after vaccination, there is no evidence that these were due to the vaccine. Some people may experience heavier than normal periods in the month or so after vaccination. They can be caused by a variety of factors including stress and other short-term illnesses. Can the vaccine cause irregular periods or unexpected bleeding? As with all vaccines, you can report suspected side effects through the Yellow Card website. Millions of people have had a coronavirus vaccine and the safety of the vaccines continues to be monitored. feelings of having a fast-beating, fluttering, or pounding heart.You should seek medical advice urgently if, after vaccination, you experience: Most of the people affected have felt better and recovered quickly following rest and simple treatments. These rare cases have been seen mostly in younger men and within several days of vaccination. Very rare side effects Heart inflammationĬases of inflammation of the heart (called myocarditis or pericarditis) have been reported very rarely after the coronavirus vaccine. If you are due for breast screening (a mammogram) then you should mention that you have had the vaccine when you attend. If it lasts longer, speak to your health professional. Uncommon side effects Swollen glands in the armpit or neckĪn uncommon side effect is swollen glands in the armpit or neck, on the same side as the arm where you had the vaccine.
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